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Description
Bead Method for the Detection of Sperm-Reactive IgG Antibodies
Features
- 100 determinations per reagent recommended as a replacement to the ImmunoBeads™ Test
- Improvement over IBT- see comparison below
- 18-month shelf life
Background Information
There is considerable evidence that antibodies directed against sperm surface antigens exert a fertility-reducing effect. When antisperm antibodies are present, they bind to the surface of the sperm. Such sperm-bound antibodies may impair sperm movement, penetration of the cumulus and/or zona pellucida, the acrosome reaction, interaction of sperm and egg as well as identify the sperm for destruction by the immune system. It has also been suggested that sperm antibodies may exert an embryotoxic effect. Finally, there is evidence that antibody concentration is correlated directly with the severity of sperm functional impairment and inversely with potential fertilisability.
For these reasons, many reproductive specialists screen sperm and/or serum for anti-sperm antibodies before choosing an appropriate Assisted Reproductive Technology.
Product Specification
| Features | ImmunoSpheres |
| Beads | Mono-dispersed |
| Bead Size | Uniform 3.0um latex beads |
| Bead Colour |
Blue for Anti-IgG Blue for Anti-IgA Blue for Anti-IgM |
| Bead Preparation | Wash each time |
| Microscopy | Bright field of phase contrast |
| Shelf Life | 18 months |
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